Endocrine Abstracts

Background/objectives: We have previously shown the existence of a pancreatic islet renin-angiotensin system and its key component AT1 receptor (AT1R) was upregulated in an obese Type 2 diabetes mellitus (T2DM) mouse model. Blockade of the AT1R was found to improve beta-cell function and glucose-stimulated insulin secretion in this T2DM model. However, the mechanism(s) remain equivocal. In this context, oxidative stress was suggested to be a critical regulator for t...

Objectives: We have recently identified an islet renin-angiotensin system in the pancreas which was subjected to upregulation in an obesity-induced mouse model of Type 2 diabetes mellitus (T2DM). Blockade of the AT1 receptor (AT1R) activation in this diabetic model improves islet function. It is well known that hyperglycemia plays a pivotal role in beta-cell dysfunction and T2DM. Nevertheless, glucotoxicity-induced AT1R activation and its consequence in oxidative st...